My prior boat had an IO. I originally wanted an IO. However, after researching the topic and talking to people, including boat mechanics, I went with the OB. My main reason was because the floor plan I wanted was not available with the IO. I do not like loungers nor a deck with a step up for many reasons. Hence, the choice was already made as the OB was my only choice. Plus, the OB, as mentioned by spinzone, is lighter and easy to access and cheaper to work on. I also like the ability to tilt the motor all the way up for certain reasons.
You will need to determine what best fits your needs on all levels and then the choice of the type of motor may become clear. As I say in other area's, the mission will dictate the gear.
Cheers, Steve